Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1mg/kg.
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منابع مشابه
8-OH-DPAT (5-HT1A agonist) Attenuates 6-Hydroxy- dopamine-induced catalepsy and Modulates Inflammatory Cytokines in Rats
Objective(s): Neuroinflammation in Parkinson disease (PD) is associated with glial cells activation and production of different inflammatory cytokines. In this study, we investigated the effect of chronic administration of 8-OH-DPAT on 6-OHDA-induced catalepsy and levels of inflammatory cytokines in cerebrospinal fluid (CSF). Materials and Methods: Catalepsy was induced by un...
متن کاملTandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series
This case report details the therapeutic effects of tandospirone on two patients with anorexia nervosa, one with the restricting subtype (ANR), and another with the binge-eating/purging subtype (ANBP). A 22-year-old female patient with ANR and a 23-year-old female patient with ANBP were treated successfully with the 5-HT1A partial agonist tandospirone. After treatment, not only did both patient...
متن کامل5-HT1A receptor agonist Befiradol reduces fentanyl-induced respiratory depression, analgesia, and sedation in rats.
BACKGROUND There is an unmet clinical need to develop a pharmacological therapy to counter opioid-induced respiratory depression without interfering with analgesia or behavior. Several studies have demonstrated that 5-HT1A receptor agonists alleviate opioid-induced respiratory depression in rodent models. However, there are conflicting reports regarding their effects on analgesia due in part to...
متن کاملPhrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats.
Activation of serotonin 1A (5-HT(1A)) receptors has been shown to have diverse effects on respiration. The purpose of this study was to determine changes in respiratory motor pattern of phrenic nerve activity and respiratory rhythm after systemic application of specific 5-HT(1A) receptor agonist 8-hydroxy-2-di-npropylamino-tetralin (8-OH-DPAT). We hypothesized that systemic application of speci...
متن کامل8-oh-dpat (5-ht1a agonist) attenuates 6-hydroxy- dopamine-induced catalepsy and modulates inflammatory cytokines in rats
objective(s): neuroinflammation in parkinson disease (pd) is associated with glial cells activation and production of different inflammatory cytokines. in this study, we investigated the effect of chronic administration of 8-oh-dpat on 6-ohda-induced catalepsy and levels of inflammatory cytokines in cerebrospinal fluid (csf). materials and methods: catalepsy was induced by unilateral infusion...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2015
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2015.09.008